COM4S_M.TTF

Research Focus

Dr. Lin and his Signal Transduction Laboratory team study molecular mechanisms of induction of apoptosis in cancer cells. Most of these mechanisms are p53-dependent and involve pharmacologic approaches to post-translational modifications of mutated, as well as wild-type, p53 or other transactivator proteins to promote programmed cell death. The post-translational modifications are dictated by signal transduction cascades. Human cancer cell models include prostate, breast, lung and head-and-neck tumors.

Other studies in the laboratory include membrane-initiated actions of non-peptide hormones, identification of membrane receptor proteins for non-peptide hormones and post-translational modifications of the superfamily of nuclear hormone receptors. The contribution of prostaglandins to tumorigenesis is also studied.

Selected Publications

• Zhang SL, Cao JH, Davis FB, Tang HY, Davis PJ and Lin HY. 2004. Estrogen inhibits resveratrol-induced posttranslational modification of p53 and apoptosis in breast cancer cells. Brit. J. Cancer 91:178-185.
• Michtalik HJ, Narayan AV, Bhatt N, Lin HY, Mulligan MT, Zhang S and Crawford, DR. 2004. Multiple oxidative stress-response members of the Adapt78 family. Free Radic Biol Med. 37:454-462.
• Shih A., Zhang S. L., Cao, J. H., Boswell, S., Wu, Y-S, Tang, H. Y., Lennartz, M. R., Davis FB, Davis PJ, and Lin HY. 2004. Inhibitory effect of EGF on resveratrol-induced apoptosis in prostate cancer cells is mediated by protein kinase C-alpha. Mol. Cancer Ther. 3:1355-1364.
• Parikh RR, Gildener-Leapman N, Narendran A, Lin HY, Lemanski N, Bennett JA, Jacobson HI and Andersen TT. 2005. Prevention of N-methyl-N-nitrosourea-induced breast cancer by alpha-fetoprotein (AFP)-derived peptide, a peptide derived from the active site of AFP. Clin Cancer Res. 23:8512-8520
• Davis FB, Tang HY, Shih A, Keating T, Lansing L, Hercbergs A, Fenstermarker RA, Mousa S, Mousa A, Davis PJ and Lin HY. 2006. Acting via cell surface receptor, thyroid hormone is a growth factor for glioma cells. Cancer Res. 66:7270-7275.
• Lin HY, Lansing L, Merillon J-M, Davis, FB, Tang, HY, Shih A, Vitrac X, Krisa S, Keating T, Cao HJ, Bergh JJ, and Davis PJ. 2006. Integrin alpha(V)beta3 contains a receptor site for resveratrol. FASEB J. 20:1742-1744.
• Tang HY, Shih A, Cao JH, Davis FB, Davis PJ and Lin HY. 2006. Inducible COX-2 facilitates p53-dependent apoptosis in human breast cancer cells. Mol Cancer Ther. 5:2034-204.
• Lin HY, Tang HY, Shih A, Keating T, Cao G, Davis PJ and Davis FB. 2007. Thyroxine induces MAPK activation and blocks resveratrol-induced apoptosis in human thyroid cancer cell lines. Steroids 72:180-187.